SAM-e

Scientific Name:  S-adenosyl methionine (C15H23N6O5S+).

Other Names:  SAM.

SAM-e (the name under which SAM is often sold as a supplement in the United States) is a cofactor in methyl group transfers, used in pathways such as transmethylation, aminopropylation, and transsulfuration. 

These processes occur throughout the body. 

The reactions by which SAM-e is produced, consumed, and regenerated are called the SAM cycle.

Forms of SAM-e: 

As an oral supplement, SAM-e is sold as a coated tablet in doses ranging from 400-1000mg and may take up to one month of treatment to reach full effectiveness. 

For the purpose of stability, oral drugs are sold in a stable salt format.

Sources of SAM-e:

SAM-e is produced and consumed mainly in the liver. 

It is a product of ATP (adenosine triphosphate) and methionine.

Home Remedies using Sam-e:

Benefits and Uses of SAM-e:

More than 40 metabolic reactions within the body involve the transfer of a methyl group from SAM-e to nucleic acids, lipids, proteins, and other substrates. 

SAM-e is required for cellular growth and repair and is necessary for the synthesis of hormones and neurotransmitters that are involved in mood control, such as serotonin or dopamine. 

It can also be attributed to the biosynthesis of several polyamines, such as spermidine and putrescine.

As a supplement, SAM-e is touted to help fight liver disease, pain caused by osteoarthritis, and even depression. 

New evidence shows that abnormally low levels of SAM-e may contribute to the development of Alzheimer’s disease, and studies prove that supplementary SAM-e can prevent oxidative damage and cognitive impairment that may be the root cause of many symptoms of the disease.

Side Effects of SAM-e:

Mild symptoms associated with SAM-e supplementation include:

• anxiety
• headache
• insomnia
• allergy
• rash
• diarrhea or other gastrointestinal disorder
• dyspepsia
• some psychiatric conditions

Individuals with cardiovascular disorders may have experience an increased risk of heart attack or stroke and should consult with their doctors prior to use.

Additional Information for SAM-e:

Storage in a cool, dry place can help to prevent deterioration, and tablets packaged in foil or foil blister packs can increase stability and absorption of the product.